{"id":4720,"date":"2023-02-22T12:21:55","date_gmt":"2023-02-22T15:21:55","guid":{"rendered":"https:\/\/innovarlaboratorios.com.ar\/?p=4720"},"modified":"2023-02-22T12:41:26","modified_gmt":"2023-02-22T15:41:26","slug":"envejecimiento-en-pets","status":"publish","type":"post","link":"https:\/\/innovarlaboratorios.com.ar\/en\/envejecimiento-en-pets\/","title":{"rendered":"Envejecimiento en pets"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"4720\" class=\"elementor elementor-4720\">\n\t\t\t\t\t\t<section data-wpr-sticky-section=\"yes\" data-wpr-position-type=\"sticky\" data-wpr-position-offset=\"0\" data-wpr-position-location=\"top\" data-wpr-sticky-devices=\"mobile_sticky tablet_sticky widescreen_sticky desktop_sticky\" data-wpr-custom-breakpoints=\"\" data-wpr-active-breakpoints=\"mobile_sticky tablet_sticky widescreen_sticky desktop_sticky\" data-wpr-z-index=\"10\" data-wpr-sticky-hide=\"\" data-wpr-replace-header=\"\" 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class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-712\"><a href=\"https:\/\/innovarlaboratorios.com.ar\/en\/contacto-innovar-laboratorios\/\" class=\"wpr-mobile-menu-item menu-link\">Contact<\/a><\/li>\n<\/ul><\/nav>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-823abae elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"823abae\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e79d4ea\" data-id=\"e79d4ea\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45f5a89 elementor-widget elementor-widget-text-editor\" data-id=\"45f5a89\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 20-03-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><span style=\"color: #ff9900;\"><a style=\"color: #ff9900;\" href=\"https:\/\/innovarlaboratorios.com.ar\/en\/blog\/\">Blog<\/a> &gt; Food Biotechnology<br \/><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63c73bd elementor-widget elementor-widget-heading\" data-id=\"63c73bd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 20-03-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Envejecimiento en Pet's<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7034b72 elementor-widget elementor-widget-heading\" data-id=\"7034b72\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">El envejecimiento en las mascotas<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2721050 elementor-widget elementor-widget-heading\" data-id=\"2721050\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Dr. Rub\u00e9n Ares<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-19b50dc elementor-widget elementor-widget-image\" data-id=\"19b50dc\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.20.0 - 20-03-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1280\" src=\"https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920.jpg\" class=\"attachment-full size-full wp-image-4722\" alt=\"\" srcset=\"https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920.jpg 1920w, https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920-300x200.jpg 300w, https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920-1024x683.jpg 1024w, https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920-768x512.jpg 768w, https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920-1536x1024.jpg 1536w, https:\/\/innovarlaboratorios.com.ar\/wp-content\/uploads\/2023\/02\/dog-2579885_1920-18x12.jpg 18w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7bef940 elementor-drop-cap-yes elementor-drop-cap-view-default elementor-widget elementor-widget-text-editor\" data-id=\"7bef940\" data-element_type=\"widget\" data-settings=\"{&quot;drop_cap&quot;:&quot;yes&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Todos envejecemos, simplemente, por la segunda ley de la termodin\u00e1mica, la Entrop\u00eda.<\/p>\n<p>En los \u00faltimos a\u00f1os, sobre todo desde comienzos del siglo XXI, muchos cient\u00edficos se concentraron en el tema. A partir del 2006, con el descubrimiento de Yamanaka sobre los genes que regulan primero el envejecimiento y luego la indiferenciaci\u00f3n celular, las c\u00e9lulas iPS que le vali\u00f3 el premio Nobel en 2012. Se desat\u00f3 una especie de fiebre del oro, conjuntamente con el estudio bioqu\u00edmico de un simp\u00e1tico gusanito el Caenorabditis elegans y su aumento de la longevidad.<\/p>\n<p>Para nombrar solo algunos de ellos que siguieron los pasos de Shinsha Yamanaka, son los Dres. Juan Carlos Izpizua Belmonte, Manuel Serrano, David Sinclair, Carmen Salgado S\u00e1nchez, Rodolfo Goya, Mar\u00eda Blasco, Roberto Grau, Carlos L\u00f3pez Ot\u00edn y much\u00edsimos m\u00e1s.<\/p>\n<p><\/p>\n<p>Antes de continuar dir\u00e9 que solo existen en la actualidad TRES mecanismos que logran el rejuvenecimiento EL FACTOR DE CRECIMIENTO INSUL\u00cdNICO (IGF), LAS C\u00c9LULAS MADRES embrionarias o tronculares y LOS FACTORES o Genes de Yamanaka (OSKM).<\/p>\n<p>Las dem\u00e1s propuestas AYUDAN o son CONSECUENCIA de los tres mecanismos antes mencionados que luego describir\u00e9.<\/p>\n<p>Los ANTIOXIDANTES, LOS ENERG\u00c9TICOS de las mitocondrias, los estimulantes de la muerte de las C\u00e9lulas senescentes, los eliminadores de restos t\u00f3xicos de detritus celulares, los normo homeost\u00e1ticos celulares, los tel\u00f3meros y telomerasa, probi\u00f3ticos y etc. son el caso.<\/p>\n<p><\/p>\n<p class=\"c1\"><span class=\"c6 c0\"><b>Factor del crecimiento insul\u00ednico<\/b><\/span><\/p>\n<p class=\"c1 c3\">\n<\/p><p class=\"c1\"><span class=\"c5\">Son una serie de prote\u00ednas, de alta similitud de secuencia con la INSULINA, este complejo factor consiste en 2 receptores de membrana plasm\u00e1tica, 2 ligandos y 6 prote\u00ednas transportadoras que conjuntamente con unas enzimas proteol\u00edticas forman este sistema.<\/span><\/p>\n<p class=\"c1\"><span class=\"c5\">Este sistema est\u00e1 regulado por el GENOMA y el EPIGENOMA, por lo tanto, dependen de un gran n\u00famero de variantes que terminan regulando su expresi\u00f3n.<\/span><\/p>\n<div>\n<p class=\"c1\"><span class=\"c6 c0\"><b>Las c\u00e9lulas madre<\/b><\/span><\/p>\n<p class=\"c1 c3\">\n<\/p><p class=\"c1\"><span class=\"c4\">Debemos dividirlas en las de temprana generaci\u00f3n en el feto y las <\/span><span class=\"c7 c4\">adultas, <\/span><span class=\"c4\">que por mecanismos logran <\/span><span class=\"c7 c4\">rejuvenecer <\/span><span class=\"c2\">e indiferenciarse.<\/span><\/p>\n<p class=\"c1\"><span class=\"c2\">Estas c\u00e9lulas madre pueden generar cualquiera de las m\u00e1s de 250 tipos de c\u00e9lulas que poseen los mam\u00edferos, reemplazar a las viejas o senescentes y dar una nueva vitalidad al tejido u \u00f3rgano.<\/span><\/p>\n<p class=\"c1 c3\">\n<\/p><p class=\"c1\"><span class=\"c6 c0\"><b>Genes o Factores de Yamanaka<\/b><\/span><\/p>\n<p class=\"c1 c3\">\n<\/p><p class=\"c1\"><span class=\"c4\">Estos fueron originariamente 4 &nbsp;<\/span><span class=\"c0\">Oct4, Sok2, Klf4 y c-Myc<\/span><span class=\"c4\">, a los que luego se le agregaron 2 m\u00e1s. Hoy puedo decir que son seguros los 3 primeros, ya que existe una extra\u00f1a relaci\u00f3n entre 2 grandes temas de la ciencia<\/span><span class=\"c0 c6\">&nbsp;El c\u00e1ncer y el rejuvenecimiento.<\/span><span class=\"c4\"> Con los primeros 3 <\/span><span class=\"c0\">(OSK<\/span><span class=\"c2\">), se logra el efecto deseado y se evitan problemas de posibles oncog\u00e9nesis. La t\u00e9cnica de uso ser\u00eda inocular plaquetas con estos genes en plasma aut\u00f3logo y reinyectar en forma endovenosa el mismo.<\/span><\/p>\n<p class=\"c1 c3\">\n<\/p><p class=\"c1 c3\">\n<\/p><p class=\"c1\"><span class=\"c4\">Hoy podemos decir que se mencionan, m\u00e1s de 200 substancias \u00a8antiage\u00a8, pero debemos considerarlas como<\/span><span class=\"c0\">&nbsp;AYUDA <\/span><span class=\"c2\">a los procesos antes descritos.<\/span><\/p><p class=\"c1\"><span class=\"c2\">Tanto antioxidantes, que mejoran el funcionamiento de la membrana plasm\u00e1tica y nuclear (Resveratrol, vitamina C, flavonoides, astaxantinas, etc.) como energ\u00e9ticos del funcionamiento de las mitocondrias (ATP, NAD, etc.), muerte de c\u00e9lulas senescentes o zombis (Rapamicina, Espermicina, Restricci\u00f3n cal\u00f3rica, Estimulantes de la telomerasa, etc.). Modificadores de la expresi\u00f3n gen\u00e9tica (las sirtuinas), Son ayudas importantes, pero no garantizan un verdadero rejuvenecimiento.<\/span><\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0fba10 elementor-widget elementor-widget-text-editor\" data-id=\"a0fba10\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-36aeddc\" data-id=\"36aeddc\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b043f89 elementor-widget elementor-widget-image\" data-id=\"b043f89\" 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data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Copyright \u00a9 2022 Innovar Laboratorios<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Productos Blog Quienes somos Contacto Productos Blog Quienes somos Contacto Blog &gt; Biotecnolog\u00eda alimentaria Envejecimiento en Pet&#8217;s El envejecimiento en las mascotas Dr. Rub\u00e9n Ares Todos envejecemos, simplemente, por la segunda ley de la termodin\u00e1mica, la Entrop\u00eda. En los \u00faltimos a\u00f1os, sobre todo desde comienzos del siglo XXI, muchos cient\u00edficos se concentraron en el tema. [&hellip;]<\/p>","protected":false},"author":1,"featured_media":4722,"comment_status":"closed","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"site-sidebar-layout":"right-sidebar","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[21,22],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Envejecimiento en pets<\/title>\n<meta name=\"description\" content=\"Todos envejecemos, simplemente, por la segunda ley de la termodin\u00e1mica, la Entrop\u00eda. 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